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Specialty Oncology , gynecology Symptoms Early: When an ovarian malignancy is included in a list of diagnostic possibilities, a limited number of laboratory tests are indicated. One major problem with screening is no clear progression of the disease from stage I noninvasive to stage III invasive is seen, and it may not be possible to find cancers before they reach stage III. Thus not having children is a risk factor for ovarian cancer, likely because ovulation is suppressed via pregnancy. For platinum-sensitive tumors, platins are the drugs of choice for second-line chemotherapy, in combination with other cytotoxic agents.